TAMPA, Fla. -- Receiver Amarri Jackson ran for two touchdowns and threw for a third Saturday night to lead South Florida to the biggest victory in the school's brief football history, a 45-14 rout of No. 9 Louisville in the Bulls' Big East debut.

South Florida wide receiver Amarri Jackson (18) outruns Louisville defenders Brandon Johnson, left, and Rod Council, right, to score on a 51-yard touchdown reception during the second quarter Saturday night Sept 24, 2005, in Tampa, Fla. (AP Photo/Chris O'Meara)

After barely playing a role in the offense in his team's first three games, Jackson was Mr. Versatile in helping South Florida (3-1) beat a ranked opponent for the first time in six tries and stop the nation's third-longest Division I-A winning streak at nine games.

Louisville (2-1) had not lost since a 41-38 setback at Miami last Oct. 14. The Cardinals entered the conference opener with one of the country's most prolific offenses, but never fully got on track in losing to South Florida on the road for the second time in three years.

USF, which is in its ninth season, also upset Louisville two years ago in the Bulls' Conference USA debut. The Bulls and Cardinals left C-USA for the higher profile Big East after last season.

Jackson, who had two receptions for 15 yards in South Florida's first three games, set up Andre Hall's 1-yard, first-quarter TD run with a 57-yard catch-and-run on the Bulls' second offensive play.

The 6-foot-5 receiver scored on a 51-yard reverse up the right side of the field to make it 14-0, then circled left end on a 12-yard reverse for a 21-0 lead midway through the second quarter.

Three minutes after South Florida's Chad Simpson returned the second-half kickoff 94 yards for a touchdown, Jackson struck again when took a handoff from quarterback Pat Julmiste and tossed an 11-yard scoring pass to Derek Carter to put the Bulls ahead 38-7.

Jackson finished with 63 yards rushing on two carries and two receptions for 75 yards. Hall, who added a 3-yard TD run in the fourth quarter, gained 83 rushing on 22 attempts, while Julmiste was 4-for-9 for 93 yards passing.

Despite the lopsided score, Louisville again compiled some gaudy offensive statistics with Brian Brohm completing 29 of 47 passes for 389 yards, and the Cardinals amassing 493 yards total offense to South Florida's 355.

But a week after throwing for five touchdowns to help the Cardinals overcome a slow start to beat Oregon State 63-27, the sophomore quarterback was intercepted once and stymied repeatedly by penalties and a relentless pass rush.

Michael Bush scored both of Louisville's touchdowns on 1-yard runs.